When your dog isn’t feeling well, it’s normal to wonder if there’s something in your own medicine cabinet that could help. But giving dogs human medications can be risky, and even familiar over-the-counter drugs can cause serious harm when used incorrectly.

While nothing replaces guidance from your veterinarian, especially when it comes to dosing or sudden symptoms, it can be helpful to understand which medications are sometimes used in dogs and which should never be given under any circumstance.

This list is NOT a substitute for veterinary advice. Always speak with your vet first.

Benadryl (Diphenhydramine)

Benadryl is one of the most commonly used over-the-counter medications in dogs. Most dogs can take Benadryl safely when used correctly and in vet-approved doses. It’s often used to help manage:

• Seasonal allergies
• Mild environmental allergies
• Itching from insect bites
• Mild sedation before stressful events or travel

Use extra caution with toy breeds, seniors, or dogs taking other medications, as they may be more sensitive.

Dramamine (Dimenhydrinate)

Dramamine is occasionally used to help dogs who experience motion sickness. It can help reduce:

• Nausea
• Drooling
• Vomiting during car rides

However, it often causes sleepiness. So it’s best to test the medication at home first so you know how your dog responds before travelling.

MiraLAX (Polyethylene Glycol 3350)

For mild constipation, some veterinarians recommend MiraLAX. It’s essentially extra fiber that helps promote regular bowel movements and works as a gentle stool softener.

Start with a very small amount and monitor your dog closely. Too much can cause diarrhea or abdominal discomfort.

Prilosec (Omeprazole)

Prilosec reduces stomach acid and may help dogs who experience:

• Upset stomach
• Mild gastric irritation
• Acid-related vomiting after certain foods

However, persistent or sudden vomiting should never be ignored, as it can indicate a more serious underlying issue.

Hydrocortisone

Hydrocortisone can be useful for small, localized areas of inflammation, such as hot spots, insect bites, or irritated patches of skin. Sprays are often preferred over creams because they’re harder for dogs to lick off.

Avoid applying hydrocortisone near the eyes, inside the ears, or on broken skin unless directed by your veterinarian.

OTC Medications That Are NOT Safe for Dogs

Some pain relievers that seem harmless to humans are extremely dangerous for dogs. These medications can cause severe toxicity, internal bleeding, organ failure, and even death.

Never give your dog:

• Acetaminophen (Tylenol)
• Ibuprofen (Advil, Motrin)
• Aspirin

If your dog appears to be in pain, always call your veterinarian before giving anything—even something you’ve taken safely yourself.

When to Call Your Veterinarian

If you’re unsure about dosing, whether a medication is safe, or what symptoms mean, your veterinarian is the best resource. Always reach out if:

• Your dog’s symptoms come on suddenly
• A new behavior or symptom doesn’t make sense
• You’re unsure whether a medication is appropriate
• You’re treating a condition for the first time
• Symptoms worsen or don’t improve after giving an OTC medication

Your vet can help you choose safe options tailored to your dog’s weight, age, breed, and medical history.

This content is for educational purposes only and should not be used to diagnose or treat your dog. Always speak with your veterinarian first!